Although eosinophils are present in a range of eosinophil-associated diseases, there are some in which activated eosinophils perpetuate eosinophilic inflammation and mediate organ dysfunction through interactions with structural tissue cells and other immune cells.1–5 In these conditions where eosinophils may drive disease, such as severe eosinophilic asthma (SEA), eosinophilic granulomatosis and polyangiitis (EGPA), and hypereosinophilic syndrome (HES), unresolved eosinophilic inflammation can result in potentially irreversible reduced organ/tissue function.1,3,4,6
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